With his cousin Ludivico, and his brother Agostino, Annibale established an academy in Bologna based on the traditions from the High Renaissance, especially careful preparation, study of anatomy and drawing from life. At 35 Annibale travelled to Rome to commence the decoration of the Farnese Palace, thus re-establishing Rome as the creative centre of painting. This work reveals evidence of naturalism from Bologna, light from Venice and grandeur from Rome. St Margaret, a 3rd century Christian martyr, refused to renounce her faith to marry so was devoured by Satan in the form of a dragon. The cross she carried caused the dragon’s belly to burst open releasing her and she is shown crushing the serpent with her foot. The motto may refer to her gesture, which entreats us to lift up our hearts to the Lord.